Gut-liver axis at the frontier of host-microbial interactions
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چکیده
منابع مشابه
Gut-liver axis at the frontier of host-microbial interactions.
Liver and intestine are tightly linked through the venous system of the portal circulation. Consequently, the liver is the primary recipient of gut-derived products, most prominently dietary nutrients and microbial components. It functions as a secondary "firewall" and protects the body from intestinal pathogens and other microbial products that have crossed the primary barrier of the intestina...
متن کاملMINI-REVIEW Microbiome and Host Interactions Gut-liver axis at the frontier of host-microbial interactions
Brandl K, Kumar V, Eckmann L. Gut-liver axis at the frontier of hostmicrobial interactions. Am J Physiol Gastrointest Liver Physiol 312: G413–G419, 2017. First published February 23, 2017; doi:10.1152/ajpgi.00361.2016.—Liver and intestine are tightly linked through the venous system of the portal circulation. Consequently, the liver is the primary recipient of gut-derived products, most promine...
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Over the last 10-15 years, our understanding of the composition and functions of the human gut microbiota has increased exponentially. To a large extent, this has been due to new 'omic' technologies that have facilitated large-scale analysis of the genetic and metabolic profile of this microbial community, revealing it to be comparable in influence to a new organ in the body and offering the po...
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The composition and activity of the gut microbiota codevelop with the host from birth and is subject to a complex interplay that depends on the host genome, nutrition, and life-style. The gut microbiota is involved in the regulation of multiple host metabolic pathways, giving rise to interactive host-microbiota metabolic, signaling, and immune-inflammatory axes that physiologically connect the ...
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Alcoholic liver disease (ALD) is one of the leading causes of liver diseases and liver-related death worldwide. Of the many factors that contribute to the pathogenesis of ALD, gut-derived lipopolysaccharide (LPS) plays a central role in induction of steatosis, inflammation, and fibrosis in the liver. In this review, we discuss the mechanisms by which alcohol contributes to increased gut permeab...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Gastrointestinal and Liver Physiology
سال: 2017
ISSN: 0193-1857,1522-1547
DOI: 10.1152/ajpgi.00361.2016